Resveratrol — an antioxidant found in red wine, chocolate, and grapes — didn’t correlate with longevity or lower risk of cancer or cardiovascular disease when dietary intake was directly measured in a prospective study.
Older adults in the Chianti wine-making region of Italy with the top dietary intake as indicated by urinary metabolites over 9 years of follow-up, Richard D. Semba, MD, MPH, of Johns Hopkins University, and colleagues found.
In fact, Inflammatory markers, cardiovascular disease, and cancer all showed the same lack of a significant relationship with resveratrol levels.
The compound has been hailed as a possible key to red wine’s heart and other health benefits, leading to substantial supplement sales.
Although annual sales of resveratrol supplements have reached $30 million in the U.S. alone, there is limited and conflicting human clinical data demonstrating any metabolic benefits of resveratrol
There are no data concerning its safety in high doses or for long-term supplementation
Resveratrol is one of a number of polyphenols found in the skin of grapes, in cocoa powder and dark chocolate, in peanuts, and in certain roots and berries.